Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression.

@article{Kim2005AktFOXO3aSM,
  title={Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression.},
  author={H H Kim and Carsten Skurk and Henrike Maatz and Ichiro Shiojima and Yuri Ivashchenko and Suk-Won Yoon and Y. Park and Kenneth Walsh},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 8},
  pages={1042-4}
}
To identify new antiapoptotic targets of the PI3K-Akt signaling pathway in endothelial cells, adenovirus-mediated Akt1 gene transfer and oligonucleotide microarrays were used to examine Akt-regulated transcripts. DNA microarray analysis revealed that HSP70 expression underwent the greatest fold activation of 12,532 transcripts examined in human umbilical vein endothelial cells (HUVEC) transduced with constitutively active Akt1. Akt1 gene transfer increased HSP70 transcript expression by 24.8… CONTINUE READING
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