Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.

@article{Li2016AkkermansiaMP,
  title={Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.},
  author={Jin H. Li and Shaoqiang Lin and Paul M Vanhoutte and Connie W Woo and Aimin Xu},
  journal={Circulation},
  year={2016},
  volume={133 24},
  pages={2434-46}
}
BACKGROUND Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila, a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice. METHODS AND… CONTINUE READING