Akirin interacts with Bap60 and 14-3-3 proteins to regulate the expression of antimicrobial peptides in the kuruma shrimp (Marsupenaeus japonicus).

@article{Liu2016AkirinIW,
  title={Akirin interacts with Bap60 and 14-3-3 proteins to regulate the expression of antimicrobial peptides in the kuruma shrimp (Marsupenaeus japonicus).},
  author={Ning Liu and Xian-Wei Wang and Jie-Jie Sun and Lei Wang and Hong-wei Zhang and Xiao-Fan Zhao and Jin-Xing Wang},
  journal={Developmental and comparative immunology},
  year={2016},
  volume={55},
  pages={
          80-9
        }
}
Akirin is a recently discovered nuclear factor that plays important roles in innate immune responses. Akirin is a positive regulator of the NF-κB factor of the Drosophila immune deficiency (IMD) pathway, which shares extensive similarities with the mammalian tumor necrosis factor receptor (TNFR) signaling pathway. However, some studies found that the NF-κB transcriptional targets were also strongly repressed in akirin2 knockout mice following TLR, IL-1β and TNFα treatment. Therefore, the… CONTINUE READING

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