Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor.

@article{MontoyaDurango2008AjubaFA,
  title={Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor.},
  author={Diego E. Montoya-Durango and Chinavenmeni S. Velu and Avedis Kazanjian and Meghan E. B. Rojas and Chris Jay and Gregory D. Longmore and H. Leighton Grimes},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 46},
  pages={32056-65}
}
Growth factor independent-1 (Gfi1) is a zinc finger protein with a SNAG-transcriptional repressor domain. Ajuba is a LIM domain protein that shuttles between the cytoplasm and the nucleus. Ajuba functions as a co-repressor for synthetic Gfi1 SNAG-repressor domain-containing constructs, but a role for Ajuba co-repression of the cognate DNA bound Gfi1 protein has not been defined. Co-immunoprecipitation of synthetic and endogenous proteins and co-elution with gel filtration suggest that an… CONTINUE READING