Airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside.

@article{Jia1995AirwaysOA,
  title={Airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside.},
  author={Yanlin Jia and Li-xian Xu and S I Heisler and James Martin},
  journal={The American journal of physiology},
  year={1995},
  volume={269 1 Pt 1},
  pages={L85-91}
}
The aim of the current studies was to investigate the possibility that a decreased relaxant response to nitric oxide (NO) might contribute to strain-related differences in airway responsiveness in the rat. Isolated tracheal rings from hyperresponsive. Fisher rats were confirmed to be more responsive to carbachol [mean effective concentration (EC50) = 2.45 x 10(-7) M] than those from Lewis (EC50 = 3.60 x 10(-7) M, P < 0.03) and ACI (EC50 = 3.85 x 10(-7) M, P < 0.01) rats. Sodium nitroprusside… CONTINUE READING