Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.

@article{Howell1991AirwaySM,
  title={Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.},
  author={R. Howell and K. Laemont and L. Noronha-Blob},
  journal={European journal of pharmacology},
  year={1991},
  volume={196 3},
  pages={
          323-6
        }
}
  • R. Howell, K. Laemont, L. Noronha-Blob
  • Published 1991
  • Chemistry, Medicine
  • European journal of pharmacology
  • We investigated the M3/M2 antagonist selectivity of [N-iminomethyl-N'-[(2-hydroxy-2-phenyl-2-cyclohexyl)-ethyl] piperazine HCI (DAC 5945) in vivo. ED50 values for reversal of methacholine-induced bronchoconstriction and bradycardia by muscarinic antagonists were determined in anesthetized and ventilated guinea pigs. Atropine, ipratopium, pirenzepine and diphenyl-acetoxy-4-methylpiperidine methiodide (4-DAMP) were non-selective, whereas methoctramine was cardioselective. In contrast, DAC 5945… CONTINUE READING
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