Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.

Abstract

We investigated the M3/M2 antagonist selectivity of [N-iminomethyl-N'-[(2-hydroxy-2-phenyl-2-cyclohexyl)-ethyl] piperazine HCI (DAC 5945) in vivo. ED50 values for reversal of methacholine-induced bronchoconstriction and bradycardia by muscarinic antagonists were determined in anesthetized and ventilated guinea pigs. Atropine, ipratopium, pirenzepine and… (More)

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@article{Howell1991AirwaySM, title={Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.}, author={R Edward Howell and Keith D. Laemont and Lalita Noronha-Blob}, journal={European journal of pharmacology}, year={1991}, volume={196 3}, pages={323-6} }