Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

  title={Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.},
  author={Steven S. An and Tony R. Bai and Jason H. T. Bates and J. L. Black and R. H. Brown and Vito Brusasco and Pasquale Chitano and Linghong Deng and Matt Dowell and David H. Eidelman and B. Fabry and Nigel J Fairbank and Lincoln E. Ford and Jeffrey J. Fredberg and William T. Gerthoffer and Stephen H. Gilbert and Reinoud Gosens and Susan J Gunst and Andrew J Halayko and Roland H. Ingram and Charles G. Irvin and Alan L. James and Luke Jeffrey Janssen and Gregory G. King and Darryl A Knight and A M Lauzon and Oren J. Lakser and Mara S. Ludwig and Kenneth R. Lutchen and Geoffrey N. Maksym and James Martin and Thais Mauad and Brent E. McParland and Srboljub M. Mijailovich and Howard W. Mitchell and Richard W. Mitchell and Wayne Mitzner and Thomas M. Murphy and Peter D. Par{\'e} and Robert Nozick Pellegrino and Michael J. Sanderson and R. Robert Schellenberg and Chun Y Seow and Paulo S. Silveira and Paul G. Smith and Julian Solway and Newman L. Stephens and Peter J. Sterk and Alastair G Stewart and Dale D Tang and Robert S Tepper and Thai Binh Tran and Lei Wang},
  journal={The European respiratory journal},
  volume={29 5},
Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of… CONTINUE READING


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