Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma.

@article{Arm1989AirwayRT,
  title={Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma.},
  author={Jonathan P. Arm and S P O'Hickey and Bernd W Spur and Tak Hong Lee},
  journal={The American review of respiratory disease},
  year={1989},
  volume={140 1},
  pages={148-53}
}
Airway responsiveness to histamine and leukotriene E4 (LTE4) has been compared between five subjects with aspirin-induced asthma (AIA) and 15 asthmatic subjects without aspirin sensitivity (non-AIA). In the AIA group, the geometric mean doses of histamine and LTE4 causing a 35% fall in specific airway conductance (PD35) were 0.31 mumol and 0.17 nmol, respectively, and LTE4 was 1,870 times more potent than histamine. In the non-AIA group, the histamine and LTE4 PD35 doses were 0.40 mumol (non… CONTINUE READING