Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness.

@article{Gillis1999AirwayRI,
  title={Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness.},
  author={Heather L. Gillis and Kenneth R. Lutchen},
  journal={Journal of applied physiology},
  year={1999},
  volume={86 6},
  pages={2001-12}
}
Although airway remodeling and inflammation in asthma can amplify the constriction response of a single airway, their influence on the structural changes in the whole airway network is unknown. We present a morphometric model of the human lung that incorporates cross-sectional wall areas corresponding to the adventitia, airway smooth muscle (ASM), and mucosa for healthy and mildly and severely asthmatic airways and the influence of parenchymal tethering. A heterogeneous ASM percent shortening… CONTINUE READING
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