Airway reflux

@article{Johnston2016AirwayR,
  title={Airway reflux},
  author={Nikki Johnston and Frank Ondrey and Rachel Rosen and Bryan P. Hurley and Jon S. Gould and Jacquie Allen and John DelGaudio and Kenneth W. Altman},
  journal={Annals of the New York Academy of Sciences},
  year={2016},
  volume={1381}
}
An ever‐increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic… Expand
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31 Citations
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31 Citations

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Citation Type

Gastroesophageal Reflux and Respiratory Tract Symptoms
TLDR
The field of reflux-related respiratory disorders continues to evolve, however, and the challenge of caring for these pediatric patients requires a multidisciplinary team-based approach. Expand
Reflux Inhibitors and Prokinetics
TLDR
The role of each factor in the pathophysiology of GORD varies among individuals and respiratory conditions, and contribute to the heterogeneity of this syndrome. Expand
Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia
TLDR
Dysphagia and LPR both have significant overlap with numerous disease entities, and few studies show that managing LPR-related dysphagia may improve with surgical intervention if there is no improvement with conservative management. Expand
Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations
TLDR
Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators and biomarkers for reflux in the upper airway, and offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation. Expand
Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018
TLDR
Diagnosis remains controversial despite improvement in impedance and availability of pepsin detection in daily practice, and the addition of alginate or magaldrate to proton pump inhibitors should be considered. Expand
Aerodigestive Approach to Chronic Cough in Children
TLDR
There is no consensus in the literature on how to work up a child with chronic cough presenting to an aerodigestive clinic, and future studies evaluating clinical outcomes are necessary to help delineate the utility of testing routinely performed. Expand
The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review
  • J. Lechien, V. Muls, +9 authors R. Sataloff
  • Medicine
  • Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • 2019
To summarise current knowledge about the prevalence, aetiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients—those who do not respond to anti‐reflux medical treatment.
Association between gastroesophageal reflux disease and vocal fold polyps
TLDR
Pepsin may promote the aggregation of immune cells, increase the local cytokines, and promote inflammatory reaction, suggesting a potential new pathogenesis for VFP. Expand
Perspectives on the interlinked nature of systemic sclerosis and reflux disease
TLDR
This review summarizes the most recent knowledge about the pathophysiology, diagnosis and prospective treatment of GERD in SSc patients and highlights how innovative technologies applied through an integrative, interdisciplinary approach may soon lead to effective treatment strategies. Expand
Laryngopharyngeal Reflux in Chronic Rhinosinusitis
TLDR
Benefit outweighs harm for PPI treatment of postnasal drip and nasal congestion in patients with CRS and comorbid LPR and treatment of LPR with a proton pump inhibitor has been effective in treating postnasAL drip and reducing nasal resistance. Expand
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TLDR
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TLDR
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