Airway reflux

@article{Johnston2016AirwayR,
  title={Airway reflux},
  author={Nikki Johnston and Frank Ondrey and Rachel Rosen and Bryan P. Hurley and Jon S. Gould and Jacquie Allen and John DelGaudio and Kenneth W. Altman},
  journal={Annals of the New York Academy of Sciences},
  year={2016},
  volume={1381}
}
An ever‐increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic… 
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43 Citations
Highly Influential Citations
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Methods Citations
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43 Citations

Gastroesophageal Reflux and Respiratory Tract Symptoms

The field of reflux-related respiratory disorders continues to evolve, however, and the challenge of caring for these pediatric patients requires a multidisciplinary team-based approach.

Reflux Inhibitors and Prokinetics

The role of each factor in the pathophysiology of GORD varies among individuals and respiratory conditions, and contribute to the heterogeneity of this syndrome.

Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia

Dysphagia and LPR both have significant overlap with numerous disease entities, and few studies show that managing LPR-related dysphagia may improve with surgical intervention if there is no improvement with conservative management.

How to Understand and Treat Laryngopharyngeal Reflux.

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators and biomarkers for reflux in the upper airway, and offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.

Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018

Diagnosis remains controversial despite improvement in impedance and availability of pepsin detection in daily practice, and the addition of alginate or magaldrate to proton pump inhibitors should be considered.

Aerodigestive Approach to Chronic Cough in Children

There is no consensus in the literature on how to work up a child with chronic cough presenting to an aerodigestive clinic, and future studies evaluating clinical outcomes are necessary to help delineate the utility of testing routinely performed.

The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review

  • J. LechienV. Muls R. Sataloff
  • Medicine
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • 2019
To summarise current knowledge about the prevalence, aetiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients—those who do not respond to anti‐reflux medical treatment.

Association between gastroesophageal reflux disease and vocal fold polyps

Pepsin may promote the aggregation of immune cells, increase the local cytokines, and promote inflammatory reaction, suggesting a potential new pathogenesis for VFP.

Bile reflux and hypopharyngeal cancer

The most important findings that strongly support bile reflux as an independent risk factor for hypopharyngeal cancer are presented in the current review and the underlying mechanisms are provided.

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