Airway reflux

  title={Airway reflux},
  author={Nikki Johnston and Frank Ondrey and Rachel Rosen and Bryan P. Hurley and Jon S. Gould and Jacquie Allen and John DelGaudio and Kenneth W. Altman},
  journal={Annals of the New York Academy of Sciences},
An ever‐increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic… 

Gastroesophageal Reflux and Respiratory Tract Symptoms

The field of reflux-related respiratory disorders continues to evolve, however, and the challenge of caring for these pediatric patients requires a multidisciplinary team-based approach.

Reflux Inhibitors and Prokinetics

The role of each factor in the pathophysiology of GORD varies among individuals and respiratory conditions, and contribute to the heterogeneity of this syndrome.

Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia

Dysphagia and LPR both have significant overlap with numerous disease entities, and few studies show that managing LPR-related dysphagia may improve with surgical intervention if there is no improvement with conservative management.

How to Understand and Treat Laryngopharyngeal Reflux.

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators and biomarkers for reflux in the upper airway, and offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.

Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018

Diagnosis remains controversial despite improvement in impedance and availability of pepsin detection in daily practice, and the addition of alginate or magaldrate to proton pump inhibitors should be considered.

Aerodigestive Approach to Chronic Cough in Children

There is no consensus in the literature on how to work up a child with chronic cough presenting to an aerodigestive clinic, and future studies evaluating clinical outcomes are necessary to help delineate the utility of testing routinely performed.

The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review

  • J. LechienV. Muls R. Sataloff
  • Medicine
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • 2019
To summarise current knowledge about the prevalence, aetiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients—those who do not respond to anti‐reflux medical treatment.

Association between gastroesophageal reflux disease and vocal fold polyps

Pepsin may promote the aggregation of immune cells, increase the local cytokines, and promote inflammatory reaction, suggesting a potential new pathogenesis for VFP.

Bile reflux and hypopharyngeal cancer

The most important findings that strongly support bile reflux as an independent risk factor for hypopharyngeal cancer are presented in the current review and the underlying mechanisms are provided.



Evidence-based practice: reflux in sinusitis.

The role of extraesophageal reflux in medically and surgically refractory rhinosinusitis

To clarify the relationship between chronic rhinosinusitis (CRS) and extraesophageal reflux (EER) using state‐of‐the‐art technology. We hypothesized that patients with medically and surgically

Direct Nasopharyngeal Reflux of Gastric Acid is a Contributing Factor in Refractory Chronic Rhinosinusitis

It is hypothesized that refractory CRS patients have a greater incidence of laryngopharyngeal reflux and NPR events and that NPR is a significant etiologic factor for CRS in these patients.

The presence of pepsin in the lung and its relationship to pathologic gastro‐esophageal reflux

If there is a higher reflux burden as measured by pH‐MII in patients that are pepsin positive in the lung, and the sensitivity of pepsin in predicting pathologic reflux by pH, MII, and EGD is studied.

Prevalence of pediatric aspiration-associated extraesophageal reflux disease.

IMPORTANCE The role of aspiration-associated extraesophageal reflux disease (AERD) in patients with chronic respiratory symptoms is not well defined. Identifying the frequency of AERD in these

Optimal treatment of laryngopharyngeal reflux disease

There are scant conflicting results to assess the effect of reflux treatments (including dietary and lifestyle modification, medical treatment, antireflux surgery) on laryngopharyngeal reflux.

Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease

Whether pepsin has to be enzymatically active to deplete laryngeal protective proteins, carbonic anhydrase isoenzyme III (CAIII), and squamous epithelial stress protein Sep70 is determined.

Reflux Revisited: Advancing the Role of Pepsin

Today, it is recognised reflux reaches beyond the esophagus, where pepsin, not acid, causes damage, and these new insights may lead to the development of novel drugs that dramatically reduce pepinginogen secretion, block the effects of adherent pepin, and give corresponding clinical benefit.

Cough Hypersensitivity Syndrome Is an Important Clinical Concept: A Pro/Con Debate

The cough hypersensitivity syndrome has been proposed to explain the occurrence of chronic cough in a subgroup of patients exposed to the same putative triggers as the vast majority of the population in whom chronic cough does not result.

Reflux Events Detected by pH-MII Do Not Determine Fundoplication Outcome

P pH- multichannel intraluminal impedance testing may not be a useful tool in predicting fundoplication outcome, and receiver operating characteristic curve analysis failed to reveal an ideal value to maximize sensitivity for either the symptom index or the symptom sensitivity index.