Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma.

@article{Gibson2000AirwayMC,
  title={Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma.},
  author={Peter G Gibson and Nicholas Saltos and Trevor Borgas},
  journal={The Journal of allergy and clinical immunology},
  year={2000},
  volume={105 4},
  pages={752-9}
}
BACKGROUND The relationship between airway inflammation and asthma severity in corticosteroid-treated asthma is unclear. OBJECTIVES Our purpose was to characterize the inflammatory cell profile of the airway lumen and epithelium in corticosteroid-treated asthma and to relate these findings to clinical and physiologic markers of asthma severity. METHODS Adults (n = 20) with asthma received standardized high-dose inhaled corticosteroid therapy with beclomethasone 2000 microgram per day for 8… CONTINUE READING

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