Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor.

@article{Virtala2012AirwayIE,
  title={Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor.},
  author={Robert Virtala and A-K Ekman and Lennart T Jansson and Ulla Westin and L. O. Cardell},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2012},
  volume={42 4},
  pages={590-6}
}
BACKGROUND The existence of a link between inflammation in upper and lower airways is well established. It may therefore be assumed that the nose could be used to study inflammatory events in the lower airways. OBJECTIVE This study aimed to evaluate a lipopolysaccharide (LPS) nasal challenge model by investigating the effect of the CXCR2 inhibitor AZD8309 on neutrophilic inflammation. METHODS A total of 18 healthy volunteers were randomized in a placebo-controlled, double-blind, cross-over… CONTINUE READING
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