Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.

@article{Lemiere2006AirwayIA,
  title={Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.},
  author={Catherine Lemiere and Pierre Ernst and Ron Olivenstein and Yasuhiro Yamauchi and Karuthapillai Govindaraju and Mara S. Ludwig and James Martin and Qutayba A. Hamid},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={118 5},
  pages={1033-9}
}
BACKGROUND Airway inflammation assessed by bronchial biopsies demonstrates distinct eosinophilic and noneosinophilic phenotypes in severe asthma, but their relationship to other biomarkers of disease (induced sputum and nitric oxide [NO]) is not clear. OBJECTIVES We sought to compare airway inflammation using noninvasive (induced sputum, exhaled NO), and invasive (bronchial biopsies) methods in moderate and severe asthma and to assess whether induced sputum and exhaled NO would allow the… CONTINUE READING