Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6.


A genetic predisposition to nonspecific airway hyperresponsiveness (AHR) can be demonstrated in humans and in many animal models. The goal of the current study was to gain insight into the molecular mechanisms that determine AHR by mapping the genes that control this phenotype. We describe genetic studies in a mouse model of differential sensitivity to… (More)


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