Airway hyperresponsiveness induced by cationic proteins in vivo: site of action.

@article{Homma2005AirwayHI,
  title={Airway hyperresponsiveness induced by cationic proteins in vivo: site of action.},
  author={T Homma and Jason H. T. Bates and Charles G Irvin},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={289 3},
  pages={
          L413-8
        }
}
  • T. Homma, J. Bates, C. Irvin
  • Published 1 September 2005
  • Biology
  • American journal of physiology. Lung cellular and molecular physiology
Major basic protein and other native cationic proteins increase airway hyperresponsiveness when administered to the luminal surface of the airways in vitro. To determine whether the same applies in vivo, we assessed airway responsiveness in rats challenged with both aerosolized and intravenously infused methacholine. We partitioned total lung resistance into its airway and tissue components using the alveolar capsule technique. Neither poly-l-lysine nor major basic protein altered baseline… 
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