Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration.

@article{Skloot1995AirwayHI,
  title={Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration.},
  author={Gwen Skloot and Solbert Permutt and Alkis G. Togias},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 5},
  pages={2393-403}
}
We hypothesized that hyperresponsiveness in asthma is caused by an impairment in the ability of inspiration to stretch airway smooth muscle. If the hypothesis was correct, we reasoned that the sensitivity to inhaled methacholine in normal and asthmatic subjects should be the same if the challenge was carried out under conditions where deep inspirations were prohibited. 10 asthmatic and 10 normal subjects received increasing concentrations of inhaled methacholine under conditions where forced… CONTINUE READING
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Showing 1-10 of 18 references

Impor - tance of the time interval between FEV , measurements in a methacholine provocation test

  • K. Larsson
  • Am . Rev . Respir . Dis .
  • 1993

Parenchy - mal interdependence and airway response to methacholine in excised dog lobes

  • T. A. Wilson, R. E. Hyatt
  • J . Appl . Physiol .
  • 1988

Spirometry : analysis of forced expiration within the time domain

  • A. Miller
  • The Lung in the Transition between Health and…
  • 1986

The slope of the dose - response curve to histamine in asthmatic and normal subjects

  • Y. Yan
  • Bull . Eur . Physiopathol . Respir .
  • 1984

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