Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure.

@article{Paveglio2011AirwayEI,
  title={Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure.},
  author={Sara A. Paveglio and Jenna B. Allard and Samantha R Foster Hodgkins and Jennifer L. Ather and Mieke Bevelander and Jana Mayette Campbell and Laurie A Whittaker LeClair and Sean M McCarthy and Albert van der Vliet and Benjamin T Suratt and Jonathan E Boyson and Satoshi Uematsu and Shizuo Akira and Matthew E Poynter},
  journal={American journal of respiratory cell and molecular biology},
  year={2011},
  volume={44 1},
  pages={11-23}
}
Indoleamine 2,3-dioxygenase (IDO) suppresses the functions of CD4(+) T cells through its ability to metabolize the essential amino acid tryptophan. Although the activity of IDO is required for the immunosuppression of allergic airway disease by the Toll-Like-Receptor 9 (TLR9) agonist, oligonucleotides comprised of cytosine and guanine nucleotides linked by phosphodiester bonds (CpG) DNA, it is unclear whether IDO expression by resident lung epithelial cells is sufficient to elicit these effects… CONTINUE READING

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Manipulating the mouse embryo: a laboratory manual

  • B Hogan, F Costantini, E Lacy, eds
  • 1986
Highly Influential
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