Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease.

@article{Wang2012AirwayEE,
  title={Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease.},
  author={Rui Wang and Joumana Ahmed and Guoqing Wang and Ibrahim Hassan and Yael Strulovici-Barel and Jacqueline Salit and Jason G. Mezey and Ronald G. Crystal},
  journal={Journal of immunology},
  year={2012},
  volume={189 5},
  pages={2217-25}
}
The TLRs are important components of the respiratory epithelium host innate defense, enabling the airway surface to recognize and respond to a variety of insults in inhaled air. On the basis of the knowledge that smokers are more susceptible to pulmonary infection and that the airway epithelium of smokers with chronic obstructive pulmonary disease (COPD) is characterized by bacterial colonization and acute exacerbation of airway infections, we assessed whether smoking alters expression of TLRs… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

TLR5: beyond the recognition of flagellin

Cellular & Molecular Immunology • 2017

Are healthy smokers really healthy?

Tobacco induced diseases • 2016
View 2 Excerpts

Similar Papers

Loading similar papers…