Airway epithelial cells promote transmigration of eosinophils in a new three-dimensional chemotaxis model.

@article{Kato2002AirwayEC,
  title={Airway epithelial cells promote transmigration of eosinophils in a new three-dimensional chemotaxis model.},
  author={Yasuo Kato and Tomoyuki Fujisawa and Michiko Shibano and Tadahito Saito and W Gatto and Hiroyuki Kamiya and Koichi Hirai and Motoo Sumida and Osamu Yoshie},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2002},
  volume={32 6},
  pages={
          889-97
        }
}
BACKGROUND Prominent infiltration of eosinophils in airway mucosa is the pathognomonic sign of asthma. The role of airway epithelial cells in eosinophil infiltration, however, has not been fully elucidated. OBJECTIVE The aim of this study is to develop a new in vitro transmigration system composed of airway epithelial cells and extracellular matrix, and to investigate the role of airway epithelial cells in eosinophil infiltration. METHODS A layer of type I collagen gel was formed in Netwell… CONTINUE READING