Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment.

@article{Mayer2008AirwayEC,
  title={Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment.},
  author={Anja K. Mayer and Holger Bartz and Fabian Fey and Lotte M. Schmidt and Alexander H Dalpke},
  journal={European journal of immunology},
  year={2008},
  volume={38 6},
  pages={1689-99}
}
The upper airways are prone to contact with pathogenic as well as non-pathogenic microbes, therefore immune recognition principles have to be tightly controlled. Here we show that human BEAS-2B bronchial epithelial cells inhibited secretion of the pro-inflammatory cytokines TNF-alpha and IL-12 by monocytes, macrophages and dendritic cells. This inhibitory effect could be transferred by supernatant of resting BEAS-2B cells and was also observed when primary murine tracheal epithelial cells were… CONTINUE READING

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