Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response

@inproceedings{Oh2013AirwayEC,
  title={Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response},
  author={Keunhee Oh and Myung Won Seo and Ga Young Lee and Ok-Jin Byoun and Hye Ryun Kang and Sang-Heon Cho and Dong-Sup Lee},
  booktitle={Respiratory research},
  year={2013}
}
BACKGROUND Transglutaminase 2 (TG2) is a post-translational protein-modifying enzyme that catalyzes the transamidation reaction, producing crosslinked or polyaminated proteins. Increased TG2 expression and activity have been reported in various inflammatory conditions, such as rheumatoid arthritis, inflammation-associated pulmonary fibrosis, and autoimmune encephalitis. In particular, TG2 from epithelial cells is important during the initial inflammatory response in the lung. In this study, we… CONTINUE READING
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