Airway disease in alpha-1 antitrypsin deficiency.

  title={Airway disease in alpha-1 antitrypsin deficiency.},
  author={Charlie Strange},
  volume={10 Suppl 1},
Although less well appreciated than pulmonary emphysema, inflammation of the airways is an early and important finding in alpha-1 antitrypsin deficiency (AATD). The spectrum of clinical presentations of airways disease includes cough and wheezing that is frequently diagnosed as asthma. Study of the airways inflammation in sputum or the proximal airways usually reveals neutrophilic inflammation. Although there is significant phenotypic variation, tubular airways dilation consistent with… CONTINUE READING