Airway PI3K pathway activation is an early and reversible event in lung cancer development.

@article{Gustafson2010AirwayPP,
  title={Airway PI3K pathway activation is an early and reversible event in lung cancer development.},
  author={Adam M. Gustafson and Raffaella Soldi and Christina Anderlind and Mary Beth Scholand and Jun Qian and Xiaohui Zhang and Kendal G Cooper and Darren Walker and Annette McWilliams and Gang Liu and Eva Szab{\'o} and Jerome S. Brody and Pierre P. Massion and Marc E. Lenburg and Stephen Lam and Andrea H Bild and Avrum Spira},
  journal={Science translational medicine},
  year={2010},
  volume={2 26},
  pages={
          26ra25
        }
}
Although only a subset of smokers develop lung cancer, we cannot determine which smokers are at highest risk for cancer development, nor do we know the signaling pathways altered early in the process of tumorigenesis in these individuals. On the basis of the concept that cigarette smoke creates a molecular field of injury throughout the respiratory tract, this study explores oncogenic pathway deregulation in cytologically normal proximal airway epithelial cells of smokers at risk for lung… CONTINUE READING
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