Airway PI3K pathway activation is an early and reversible event in lung cancer development.

  title={Airway PI3K pathway activation is an early and reversible event in lung cancer development.},
  author={Adam M. Gustafson and Raffaella Soldi and Christina Anderlind and Mary Beth Scholand and Jun Qian and Xiaohui Zhang and Kendal G Cooper and Darren Walker and Annette McWilliams and Gang Liu and Eva Szab{\'o} and Jerome S. Brody and Pierre P. Massion and Marc E. Lenburg and Stephen Lam and Andrea H Bild and Avrum Spira},
  journal={Science translational medicine},
  volume={2 26},
Although only a subset of smokers develop lung cancer, we cannot determine which smokers are at highest risk for cancer development, nor do we know the signaling pathways altered early in the process of tumorigenesis in these individuals. On the basis of the concept that cigarette smoke creates a molecular field of injury throughout the respiratory tract, this study explores oncogenic pathway deregulation in cytologically normal proximal airway epithelial cells of smokers at risk for lung… CONTINUE READING
Highly Cited
This paper has 114 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 68 extracted citations

DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer.

American journal of respiratory and critical care medicine • 2011
View 10 Excerpts
Highly Influenced

115 Citations

Citations per Year
Semantic Scholar estimates that this publication has 115 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 62 references

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 11 Excerpts
Highly Influenced

A phase I study of myo-inositol for lung cancer chemoprevention.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2006
View 4 Excerpts
Highly Influenced

An oncogene and emerging tumor biomarker

M. A. Gorin, Q. Pan, Protein kinase Ce
Mol. Cancer 8, 9 • 2009

Protein kinase C e : An oncogene and emerging tumor biomarker

P. K. Vogt Zhao
Mol . Cancer • 2009