Airway Hyperresponsiveness in Asthma: Mechanisms, Clinical Significance, and Treatment

  title={Airway Hyperresponsiveness in Asthma: Mechanisms, Clinical Significance, and Treatment},
  author={John D. Brannan and M. Diane Lougheed},
  booktitle={Front. Physio.},
Airway hyperresponsiveness (AHR) and airway inflammation are key pathophysiological features of asthma. Bronchial provocation tests (BPTs) are objective tests for AHR that are clinically useful to aid in the diagnosis of asthma in both adults and children. BPTs can be either "direct" or "indirect," referring to the mechanism by which a stimulus mediates bronchoconstriction. Direct BPTs refer to the administration of pharmacological agonist (e.g., methacholine or histamine) that act on specific… CONTINUE READING
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