Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.

@article{Fujikado2016AireIT,
  title={Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.},
  author={Noriyuki Fujikado and Alexander O Mann and Kushagra Bansal and Kimberly R Romito and Elise M. N. Ferre and Sergio Damian Rosenzweig and Michail S. Lionakis and Christophe Benoist and Diane Mathis},
  journal={Immunity},
  year={2016},
  volume={45 5},
  pages={999-1012}
}
Aire's primary mechanism of action is to regulate transcription of a battery of genes in medullary thymic epithelial cells (mTECs) and, consequently, negative selection of effector T cells and positive selection of regulatory T cells. We found that Aire-deficient mice had expanded thymic and peripheral populations of perinatally generated IL-17A+Vγ6+Vδ1+ T cells, considered to be "early responders" to tissue stress and drivers of inflammatory reactions. Aire-dependent control of Il7 expression… CONTINUE READING

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