• DOI:10.1093/JNCI/56.6.1125
Corpus ID: 23621126

Air-water and ether-water distribution of N-nitroso compounds: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose, and liver.

@article{Mirvish1976AirwaterAE,
  title={Air-water and ether-water distribution of N-nitroso compounds: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose, and liver.},
  author={S. Mirvish and P. Issenberg and H. Sornson},
  journal={Journal of the National Cancer Institute},
  year={1976},
  volume={56 6},
  pages={
          1125-9
        }
}

S. Mirvish, P. Issenberg, H. Sornson

Published 1976

Biology, Medicine

Journal of the National Cancer Institute

The air-water distribution ratio K1, ether-water distribution ratio K2, and solubility in water were measured for 17 nitrosamines, 3 nitrosamides, and 1 nitrosocyanamide. For K1, air was analysed either by UV absorption of ethanol extracts or by gas chromatography. K1 at 37 degrees C varied from less than 2 X 10(-6) to 4.5 X 10(-3), with 11 compounds showing K1 greater than 10(-4). A literature analysis provided data on the carcinogenicity of these N-nitroso (NNO) compounds toward the esophagus… CONTINUE READING

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