Air-water and ether-water distribution of N-nitroso compounds: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose, and liver.

@article{Mirvish1976AirwaterAE,
  title={Air-water and ether-water distribution of N-nitroso compounds: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose, and liver.},
  author={S. Mirvish and P. Issenberg and H. Sornson},
  journal={Journal of the National Cancer Institute},
  year={1976},
  volume={56 6},
  pages={
          1125-9
        }
}
  • S. Mirvish, P. Issenberg, H. Sornson
  • Published 1976
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • The air-water distribution ratio K1, ether-water distribution ratio K2, and solubility in water were measured for 17 nitrosamines, 3 nitrosamides, and 1 nitrosocyanamide. For K1, air was analysed either by UV absorption of ethanol extracts or by gas chromatography. K1 at 37 degrees C varied from less than 2 X 10(-6) to 4.5 X 10(-3), with 11 compounds showing K1 greater than 10(-4). A literature analysis provided data on the carcinogenicity of these N-nitroso (NNO) compounds toward the esophagus… CONTINUE READING
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