Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration.

@article{CalderonGarciduenas2015AirPA,
  title={Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration.},
  author={Lilian C. Calderon-Garciduenas and Aristo Vojdani and Eleonore Blaurock-Busch and Yvette M. Busch and Albrecht Friedle and Maricela Franco-Lira and Partha Sarathi-Mukherjee and Xavier Mart{\'i}nez-Aguirre and Su-Bin Park and Ricardo Torres-Jard{\'o}n and Amedeo D'Angiulli},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={43 3},
  pages={1039-58}
}
Millions of children are exposed to concentrations of air pollutants, including fine particulate matter (PM2.5), above safety standards. In the Mexico City Metropolitan Area (MCMA) megacity, children show an early brain imbalance in oxidative stress, inflammation, innate and adaptive immune response-associated genes, and blood-brain barrier breakdown. We investigated serum and cerebrospinal fluid (CSF) antibodies to neural and tight junction proteins and environmental pollutants in 139 children… CONTINUE READING