Air pollution and airway disease

  title={Air pollution and airway disease},
  author={Frank J. Kelly and Julia C. Fussell},
  journal={Clinical \& Experimental Allergy},
  • F. Kelly, J. Fussell
  • Published 1 August 2011
  • Environmental Science
  • Clinical & Experimental Allergy
Epidemiological and toxicological research continues to support a link between urban air pollution and an increased incidence and/or severity of airway disease. Detrimental effects of ozone (O3), nitrogen dioxide (NO2) and particulate matter (PM), as well as traffic‐related pollution as a whole, on respiratory symptoms and function are well documented. Not only do we have strong epidemiological evidence of a relationship between air pollution and exacerbation of asthma and respiratory morbidity… 
Respiratory health effects of air pollution: update on biomass smoke and traffic pollution.
Effects of Air Pollutants on Airway Diseases
The impact of air pollutants on airway diseases such as asthma and COPD is reviewed, focusing on their underlying mechanisms.
Air Pollution as a Risk Factor for Incident COPD and Asthma: 15-Year Population-Based Cohort Study.
  • Saeha ShinL. Bai Hong Chen
  • Medicine, Environmental Science
    American journal of respiratory and critical care medicine
  • 2020
Air pollution was associated with higher incidence of COPD, but not adult-onset asthma, and most pollutant-COPD relationships exhibited supralinear shapes.
Interstitial Lung Diseases and Air Pollution: Narrative Review of Literature
Patients with ILD should be cautious during bad-quality air days and they are advised to avoid outdoor activities and use facemasks during this period, to possibly reduce the fall in lung functions and the risk of acute exacerbations of the underlying ILD.
Air pollution and the respiratory system.
It is hoped that the relevance of investigating exposure to air pollutants and recognizing this as a risk factor that should be taken into account in the adoption of best practices for the control of the acute decompensation of respiratory diseases and for maintenance treatment between exacerbations is impressed.
Air pollution, physical activity, and markers of acute airway oxidative stress and inflammation in adolescents.
The moderating effects of activity level suggest that peaks of high concentration doses of air pollution may overwhelm the endogenous redox balance of cells, resulting in increased airway inflammation.
Air Pollution and Cytokines
This review assesses the role of inflammatory mediators in the initiation and progression of the disorders, related to air pollution, with a special focus on cytokines, which are significant intermediaries of both the innate and the adaptive immune responses.
Particulate matter air pollution and respiratory impact on humans and animals
  • C. LosaccoA. Perillo
  • Environmental Science, Biology
    Environmental Science and Pollution Research
  • 2018
The present review paper aims to summarize the current evidences and findings on the effect of air pollution on lung function in both humans and animals.
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project.
The role of air pollution in adult-onset asthma: a review of the current evidence.
The role of traffic-related air pollution in adult-onset asthma is less conclusive than in childhood asthma, and there is a need for large-scale megacohorts to investigate these effects in standardized ways and to identify the most susceptible populations.


Oxidative stress: its role in air pollution and adverse health effects
  • F. Kelly
  • Environmental Science
    Occupational and environmental medicine
  • 2003
A better appreciation of the mechanisms underlying air pollution induced health problems would allow a more targeted approach to remove the most toxic components of air pollution, and could possibly provide a means to decrease individual sensitivity to air pollution.
Air Pollution and Respiratory Viral Infection
A review of current epidemiological and experimental studies, which have examined the association between and effect of air pollutants and respiratory viral infections, as well as potential mechanisms associated with these effects, examines U.S. Environmental Protection Agency “criteria” pollutants.
Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease.
There are several possible explanations for this increased sensitivity of COPD patients to air pollution particles, including correlations of PM levels with other components of air pollution, an accumulation of multiple independent risk factors in a patient, changes in individual activity patterns, and some unique characteristic of an ambient air pollution PM.
Short-term health effects of particulate and photochemical air pollution in asthmatic children
It was shown that, although within international air quality standards, the prevailing levels of photo-oxidant and particulate pollution in spring and early summer had measurable short-term effects on children with mild-to-moderate asthma.
Exacerbations of COPD: environmental mechanisms.
Air pollution as a trigger for exacerbations of COPD has been recognized for > 50 years, and has led to the development of air quality standards in many countries that substantially decreased the
Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children.
Strong positive associations were found between the distance to the nearest main road and asthmatic bronchitis, hay fever, eczema, and sensitization and a distance-dependent relationship could be identified, with the highest odds ratios for children living less than 50 m from busy streets.
Air pollution and development of asthma, allergy and infections in a birth cohort
Air pollution was associated with respiratory infections and some measures of asthma and allergy during the first 4 yrs of life and positive associations between air pollution and specific sensitisation to common food allergens were found.
Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life.
Exposure to traffic-related air pollution may cause asthma in children and positive associations with hay fever were found in nonmovers only, and no associations were found with atopic eczema, allergic sensitization, and bronchial hyperresponsiveness.
Particulate matter exposure in children: relevance to chronic obstructive pulmonary disease.
  • J. Grigg
  • Medicine
    Proceedings of the American Thoracic Society
  • 2009
There may be significant overlap in the cellular and molecular mechanisms underlying the adverse health effects of PM in children and the development of COPD in adult smokers, since carbonaceous PM is a component of mainstream cigarette smoke.