Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs

@article{CaldernGarcidueas2008AirPC,
  title={Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs},
  author={Lilian Calder{\'o}n-Garcidue{\~n}as and Antonieta Mora-Tiscare{\~n}o and Esperanza Ontiveros and Gilberto G{\'o}mez-Garza and Gerardo Barrag{\'a}n-Mej{\'i}a and James M. Broadway and Susan Chapman and Gildardo Valencia-Salazar and Valerie Jewells and Robert R. Maronpot and Carlos F. Henr{\'i}quez-Rold{\'a}n and Beatriz Eugenia P{\'e}rez-Guill{\'e} and Ricardo Torres‐Jard{\'o}n and Lou Herrit and Diane M. Brooks and Norma Osnaya-Brizuela and Mart{\'i}n E. Monroy and Ang{\'e}lica G{\'o}nzalez‐Maciel and Rafael Reynoso-Robles and Rafael Villarreal-Calder{\'o}n and Anna C Solt and Randall W. Engle},
  journal={Brain and Cognition},
  year={2008},
  volume={68},
  pages={117-127}
}

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References

SHOWING 1-10 OF 86 REFERENCES
Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution
TLDR
Exposure to severe airpollution is associated with brain inflammation and Aβ 42 accumulation, two causes of neuronal dysfunction that precede the appearance of neuritic plaques and neurofibrillary tangles, hallmarks of Alzheimer's disease.
Air Pollution and Brain Damage
TLDR
Persistent pulmonary infl ammation and deteriorating olfactory and respiratory barriers may play a role in the neuropathology observed in the brains of these highly exposed canines.
Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults
TLDR
Air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Aβ42 and α-synuclein starting in childhood, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment.
Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology
TLDR
The findings of nasal barrier disruption, systemic inflammation, and the upregulation of COX2 and IL-1β expression and Aβ42 accumulation in brain suggests that sustained exposures to significant concentrations of air pollutants such as particulate matter could be a risk factor for AD and other neurodegenerative diseases.
Respiratory damage in children exposed to urban pollution
TLDR
The data strongly suggest that a lifelong exposure to urban air pollution causes respiratory damage in children, and a cytokine network becomes imbalanced, with a shift towards upregulation of anti‐inflammatory cytokines.
DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants Is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration
TLDR
There was an acceleration of Alzheimer's-type pathology in dogs chronically exposed to air pollutants, suggesting that Alzheimer's disease may be the sequela of air pollutant exposures and the resulting systemic inflammation.
Lung Radiology and Pulmonary Function of Children Chronically Exposed to Air Pollution
TLDR
Findings are consistent with bronchiolar, peribronchioar, and/or alveolar duct inflammation, possibly caused by ozone, PM, and lipopolysaccharide exposure, and the epidemiologic implications of these findings are important for children residing in polluted environments.
Nasal Biopsies of Children Exposed to Air Pollutants
TLDR
It is strongly suggested that children with macroscopic nasal mucosal abnormalities should be closely monitored by the ENT physician, and parents should be advised to decrease the children's number of outdoor exposure hours and encourage a balanced diet with an important component of fresh fruits and vegetables.
Elevated Plasma Endothelin-1 and Pulmonary Arterial Pressure in Children Exposed to Air Pollution
TLDR
Chronic exposure of children to PM2.5 is associated with increased levels of circulating endothelin-1 and elevated mean pulmonary arterial pressure.
Migraine as a risk factor for subclinical brain lesions.
TLDR
These population-based findings suggest that some patients with migraine with and without aura are at increased risk for subclinical lesions in certain brain areas.
...
1
2
3
4
5
...