Air Breathing and Ammonia Excretion in the Giant Mudskipper, Periophthalmodon schlosseri*

  title={Air Breathing and Ammonia Excretion in the Giant Mudskipper, Periophthalmodon schlosseri*},
  author={D. Randall and Y. Ip and S. Chew and J. M. Wilson},
  journal={Physiological and Biochemical Zoology},
  pages={783 - 788}
The giant mudskipper, Periophthalmodon schlosseri, is an amphibious, obligate, air‐breathing teleost fish. It uses its buccal cavity for air breathing and for taking and holding large gulps of air. These fish live in mud burrows at the top of the intertidal zone of mangrove mudflats; the burrow water may be hypoxic and hypercapnic and have high ammonia levels. The buccal epithelium is highly vascularized, with small diffusion distances between air and blood. The gill epithelium is densely… Expand
Active ammonia excretion in the giant mudskipper, Periophthalmodon schlosseri (Pallas), during emersion.
The results confirm for the first time that P. schlosseri can effectively excrete a high load of ammonia on land, and corroborate the proposition that active NH(4) (+) excretion through its gills contributes in part to its high tolerance of aerial exposure. Expand
Cutaneous respiration and osmoregulation in amphibious fishes.
  • P. Wright
  • Medicine, Biology
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2020
The study of amphibious fishes provides an excellent model to understand how the skin morphology and physiological mechanisms evolved to meet the dual challenges of aquatic and terrestrial environments. Expand
Theme and variations: amphibious air-breathing intertidal fishes.
  • K. Martin
  • Biology, Medicine
  • Journal of fish biology
  • 2014
With air breathing, amphibious intertidal fishes survive in a variable habitat with minimal adjustments to existing structures and closely related species in different microhabitats provide unique opportunities for comparative studies. Expand
Excretory nitrogen metabolism and defence against ammonia toxicity in air-breathing fishes.
The responses of air-breathing fishes to ameliorate ammonia toxicity are many and varied, determined by the behaviour of the species and the nature of the environment in which it lives. Expand
Ammonia as a respiratory gas in water and air-breathing fishes
  • D. Randall, Y. Ip
  • Medicine, Chemistry
  • Respiratory Physiology & Neurobiology
  • 2006
Fish have difficulties in excreting ammonia in alkaline water or high concentrations of environmental ammonia, or when out of water, so studies of these fish may offer insights into the nature of ammonia toxicity in general. Expand
Postprandial increases in nitrogenous excretion and urea synthesis in the giant mudskipper Periophthalmodon schlosseri
Together, increases in nitrogenous excretion and urea synthesis after feeding effectively prevented a postprandial surge of ammonia in the plasma of P. schlosseri throughout the 24 h period post-feeding, accompanied by a significant decrease in brain glutamine content between 12 h and 24 h. Expand
Chronic and acute ammonia toxicity in mudskippers, Periophthalmodon schlosseri and Boleophthalmus boddaerti: brain ammonia and glutamine contents, and effects of methionine sulfoximine and MK801
It can be concluded that there are major differences in mechanisms of chronic and acute ammonia toxicity between brains of these two mudskippers and mammalian brains. Expand
Ammonia and urea transporters in gills of fish and aquatic crustaceans
This review attempts to draw together recent information to update the mechanisms of ammonia and urea transport by the gills of aquatic species and points out several potentially fruitful avenues for further research. Expand
Genome sequence of walking catfish (Clarias batrachus) provides insights into terrestrial adaptation
This study provides an important genomic resource for understanding the adaptive mechanisms of walking catfish to terrestrial environments and suggests the coupling of enhanced abilities for oxygen storage and oxygen transport through genomic expansion of myoglobin genes and transcriptomic up-regulation of hemoglobin and angiogenesis-related genes are important components of the molecular basis for adaptation of this aquatic species to terrestrial life. Expand
Intermediary metabolism in mudskippers, Periophthalmodon schlosseri and Boleophthalmus boddarti, during immersion or emersion
The phosphofructose kinase-1 (PFK) from the muscle of P. schlosseri became more sensitive to ATP inhibition after 6 h of emersion, indicating that a transient decrease in the glycolytic flux indeed occurred at this locus that led to an increase in glycogen content. Expand


Fine structure of the gill epithelium of the terrestrial mudskipper, Periophthalmodon schlosseri
The unusual morphology of P. schlosseri's gill lamellae may be related to the animal's ability to effectively eliminate ammonia during air exposure and to the elimination of sodium chloride and ammonia. Expand
Results confirmed that P. schlosseri, due to its special branchial morphological and morphometric adaptation, could respire more efficiently on land than in water and became significantly more alkaline upon terrestrial exposure. Expand
The mudskippers Periophthalmodon schlosseri and Boleophthalmus boddaerti can tolerate environmental NH3 concentrations of 446 and 36µM, respectively
Results suggest that P. schlosseri might be able to maintain a low steady state level of internal ammonia during ammonia loading at a concentration which is lethal to other fishes. Expand
A comparative study of terrestrial adaptations of the gills in three mudskippers-Periophthalmus chrysospilos, Boleophthalmus boddaerti, and Periophthalmodon schlosseri
Correlations were made between differences in behavior and morphological adaptations of their gills to tolerate terrestrial exposure of the three mudskippers. Expand
Alkaline Environmental pH Has No Effect on Ammonia Excretion in the Mudskipper Periophthalmodon schlosseri but Inhibits Ammonia Excretion in the Related Species Boleophthalmus boddaerti
Experiments were performed to evaluate the effects of alkaline environmental pH on urea and ammonia excretion rates and on tissue urea, ammonia, and free amino acid concentrations in two mudskippers,Expand
Five Tropical Air‐Breathing Fishes, Six Different Strategies to Defend against Ammonia Toxicity on Land*
Modern tropical air‐breathing fishes exhibit a variety of strategies to survive on land, and they represent a spectrum of specimens through which various biochemical adaptations that would have facilitated the invasion of the terrestrial habitat by fishes during evolution are examined. Expand
Immunolocalization of ion-transport proteins to branchial epithelium mitochondria-rich cells in the mudskipper (Periophthalmodon schlosseri).
A proportion of the ammonia eliminated by P. schlosseri involves carbonic anhydrase activity and is not dependent on boundary-layer pH effects, and the apical CFTR-like anion channel may be serving as a HCO(3)(-) channel accounting for the acid-base neutral effects observed with net ammonia efflux inhibition. Expand
Partial amino acid catabolism leading to the formation of alanine in Periophthalmodon schlosseri (mudskipper): a strategy that facilitates the use of amino acids as an energy source during locomotory activity on land.
It was concluded that when P. schlosseri were active on land, they were capable of using certain amino acids as a metabolic fuel, and avoided ammonia toxicity through partial amino acid catabolism, which is the most cost-effective way of slowing down internal ammonia build-up without involving energy-expensive ammonia detoxification pathways. Expand
Studies of Ammonia in the Rainbow Trout:Physico-chemical Parameters, Acid-Base Behaviour and Respiratory Clearance
Ammonia (NH 3 ) is only slightly more soluble (+3.4%) in the plasma of rainbow trout than in water, and its pK9 is only 0.14 units higher than in fresh water at 15 °C. Determination of theseExpand
Active ammonia excretion across the gills of the green shore crab Carcinus maenas: participation of Na(+)/K(+)-ATPase, V-type H(+)-ATPase and functional microtubules.
Observations suggest a hypothetical model of transepithelial ammonia movement that features active uptake across the basolateral membrane, sequestration in acidified vesicles, vesicle transport via microtubules and exocytosis at the apical membrane. Expand