Aip regulates cAMP signalling and GH secretion in GH3 cells.

@article{Formosa2013AipRC,
  title={Aip regulates cAMP signalling and GH secretion in GH3 cells.},
  author={Robert Formosa and Angela Xuereb-Anastasi and Josanne Vassallo},
  journal={Endocrine-related cancer},
  year={2013},
  volume={20 4},
  pages={
          495-505
        }
}
Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked to predisposition to pituitary adenomas. However, the mechanism by which this occurs remains unknown. AIP interacts with a number of interesting proteins, including members of the cAMP signalling pathway that has been shown to be consistently altered in pituitary tumours. The functional role of Aip was investigated using both over-expression and knock down of Aip in GH3 cells. cAMP signalling and its… 

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Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion
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Despite co-localization in secretory vesicles, AIP and GH did not correlate at baseline or during GH stimulation or suppression tests, and AIP levels were independent of age, sex or BMI and unaffected by hypoglycaemia or hyperglycaemia.
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TLDR
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Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants.
TLDR
Improved assessment of the pathogenicity of AIP mutations is indeed paramount to provide adequate guidance for genetic counseling and clinical screening in AIP mutation carriers, which can lead to prospective diagnosis of pituitary adenomas.
cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.
TLDR
The expression of PDE4A4 and Pde4A8 in normal pituitary, their increased expression in adenomatous pituitsary cells where AIP is meant to participate, and the disruption of the PDE 4A4-AIP interaction by AIP mutants may play a role in pituitARY tumorigenesis are examined.
Phosphodiesterases and cAMP Pathway in Pituitary Diseases
TLDR
PDE4A4/5 has a unique interaction with the co-chaperone aryl hydrocarbon receptor-interacting protein (AIP), a protein implicated in somatotroph tumorigenesis via germline loss-of-function mutations, which could contribute to their well-described poor response to somatostatin analogs and may support a role in tumorsigenesis.
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