Aiming drug discovery at lysophosphatidic acid targets

@inproceedings{Tigyi2010AimingDD,
  title={Aiming drug discovery at lysophosphatidic acid targets},
  author={Gabor J Tigyi},
  booktitle={British journal of pharmacology},
  year={2010}
}
Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is the prototype member of a family of lipid mediators and second messengers. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and a nuclear hormone receptor within the cell. In addition, there are several enzymes that utilize LPA as a substrate or generate it as a product and are under its regulatory control. LPA is present in biological fluids, and attempts have been… CONTINUE READING

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