Aids-related malignancies

  title={Aids-related malignancies},
  author={Christopher Boshoff and Robin A. Weiss},
  journal={Nature Reviews Cancer},
Cancer remains a significant burden for human immunodeficiency virus (HIV)-infected individuals. Most cancers that are associated with HIV infection are driven by oncogenic viruses, such as Epstein–Barr virus, Kaposi's sarcoma-associated herpesvirus and human papillomavirus. Gaining insight into the epidemiology and mechanisms that underlie AIDS-related cancers has provided us with a better understanding of cancer immunity and viral oncogenesis. 
Aids-associated viral oncogenesis
Aids Malignancies, HIV-HBV and HIV-HCV Coinfection and Liver Cancer Development, and Human Papillomavirus Infection and Disease in the HIV+ Individual are studied.
AIDS-related malignancies
Among the chemotherapeutic agents, pegylated liposomal doxorubicin is an effective therapy for patients with HIV-linked Kaposi's sarcoma.
Mechanisms of AIDS-related lymphoma pathogenesis
It is suggested that HIV may play an indirect role in AIDS-related lymphomagenesis for a subset of tumors that do not contain detectable known oncogenic viruses.
Therapy Insight: AIDS-related malignancies—the influence of antiviral therapy on pathogenesis and management
The past decade has seen substantial improvements in the treatment of AIDS-related lymphoma, which is attributed partially to a shift in tumor type and more effective regimens and the benefits of administering HAART during therapy must be weighed against possible disadvantages.
Immune escape by Epstein-Barr virus associated malignancies.
Pathologic aspects of AIDS malignancies
The aim of this paper is to review the pathology of AIDS-related malignancies, taking into account the pathogenetic mechanisms and their potential for improving the treatment of these tumors.
Epidemiology of AIDS-related malignancies an international perspective.
Acquired immunodeficiency syndrome—related malignancies in the era of highly active antiretroviral therapy
With the development of HAART and improved prevention and treatment of opportunistic infections, an increasing percentage of the deaths in AIDS patients have been from malignancies and strategies for prevention, screening, and therapy remain important areas of research.
HIV-related hematological malignancies: a concise review.
  • A. Rios
  • Medicine
    Clinical lymphoma, myeloma & leukemia
  • 2014
Human immunodeficiency virus infection and chronic myeloid leukemia.


AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis.
The potential roles of specific cytokines and the virally encoded tat product in inducing Kaposi's sarcoma are considered.
Association of cancer with AIDS-related immunosuppression in adults.
Although occurring in overall excess, most non-AIDS-defining cancers do not appear to be influenced by the advancing immunosuppression associated with HIV disease progression.
Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome.
HPV-associated malignancies occur at increased rates in persons with HIV/AIDS, and increasing RRs for in situ cancers to and beyond the time of AIDS onset may reflect the gradual loss of control over HPV-infected keratinocytes with advancing immunosuppression.
The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
These findings indicate that HIV could play a direct part in causing cancer in mice, and that the virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice.
Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients
It is reported that the tat gene product (Tat) is released from both HIV-1-acutely infected H9 cells and tat-transfected COS-1 cells and specifically promotes growth of AIDS-KS cells which are inhibited by anti-Tat antibodies; recombinant Tat has the same growth-promoting properties.
Cytokines and Growth Factors in the Pathogenesis of AIDS‐Associated Kaposi's Sarcoma
The results from these studies indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV- 1-infected individuals.
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy.
The profile of ARL has changed since the era of HAART, with a lower incidence of systemic and brain ARL, and the prognosis of systemic ARl has improved.
Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens.
The findings suggest that the transformed B cells of AIDS-associated lymphomas may not arise from the pool of anti-HIV specific B cells but, rather, may develop from B cells responding to other antigens, including self-antigens.