Aiding and abetting roles of NOX oxidases in cellular transformation

  title={Aiding and abetting roles of NOX oxidases in cellular transformation},
  author={Karen L. Block and Yves C Gorin},
  journal={Nature Reviews Cancer},
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived… CONTINUE READING
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