AhV_aPA-induced vasoconstriction involves the IP₃Rs-mediated Ca²⁺ releasing.

  title={AhV_aPA-induced vasoconstriction involves the IP₃Rs-mediated Ca²⁺ releasing.},
  author={Fuxing Zeng and Zhisong Zou and Liwen Niu and Xin Li and Maikun Teng},
  journal={Toxicon : official journal of the International Society on Toxinology},
AhV_aPA, the acidic PLA₂ purified from Agkistrodon halys pallas venom, was previously reported to possess a strong enzymatic activity and can remarkably induce a further contractile response on the 60 mM K⁺-induced contraction with an EC₅₀ in 369 nM on mouse thoracic aorta rings. In the present study, we found that the p-bromo-phenacyl-bromide (pBPB), which… CONTINUE READING