AhR-mediated and antiestrogenic activity of humic substances.

  title={AhR-mediated and antiestrogenic activity of humic substances.},
  author={Jaroslav Janosek and Michal Bittner and Kl{\'a}ra Hilscherov{\'a} and Ludek Bl{\'a}ha and John Paul Giesy and Ivan Holoubek},
  volume={67 6},
Humic substances (HS) were for decades regarded as inert in the ecosystems with respect to their possible toxicity. However, HS have been recently shown to elicit various adverse effects generally attributed to xenobiotics. In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12… CONTINUE READING
12 Citations
27 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-10 of 27 references

Pure humic substances have the potential to act as xenobiotic chemicals – a review

  • C.E.W. Steinberg, A. Paul, S. Pflugmacher, T. Meinelt, R. Klocking, C. Wiegand
  • Fresen. Environ
  • 2003
Highly Influential
14 Excerpts

Ecology of Humic Substances in Freshwaters – Determinants from Geochemistry to Ecological Niches

  • C.E.W. Steinberg
  • 2003
Highly Influential
4 Excerpts

More evidence for humic substances acting as biogeochemicals on organisms

  • C. Wiegand, N. Meems, M. A. Timoveyev, C.E.W. Steinberg, S. Pflugmacher
  • 2003
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…