Agrobacterium tumefaciens VirB6 domains direct the ordered export of a DNA substrate through a type IV secretion System.

@article{Jakubowski2004AgrobacteriumTV,
  title={Agrobacterium tumefaciens VirB6 domains direct the ordered export of a DNA substrate through a type IV secretion System.},
  author={Simon Jakubowski and Vidhya Krishnamoorthy and Eric Cascales and Peter J Christie},
  journal={Journal of molecular biology},
  year={2004},
  volume={341 4},
  pages={961-77}
}
The Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS) translocates DNA and protein substrates across the bacterial cell envelope. Six presumptive channel subunits of this T4SS (VirD4, VirBll, VirB6, VirB8, VirB2, and VirB9) form close contacts with the VirD2-T-strand transfer intermediate during export, as shown recently by a novel transfer DNA immunoprecipitation (TrIP) assay. Here, we characterize the contribution of the hydrophobic channel component VirB6 to substrate… CONTINUE READING