Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain.

@article{Verbeek1999AgrinIA,
  title={Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain.},
  author={Marcel M Verbeek and Irene Otte-H{\"o}ller and Jacob van den Born and Lambert P. W. J. van den Heuvel and Guido David and Pieter Wesseling and Robert M. W. de Waal},
  journal={The American journal of pathology},
  year={1999},
  volume={155 6},
  pages={2115-25}
}
Heparan sulfate proteoglycans (HSPGs) have been suggested to play an important role in the formation and persistence of senile plaques and neurofibrillary tangles in dementia of the Alzheimer's type (DAT). We performed a comparative immunohistochemical analysis of the expression of the HSPGs agrin, perlecan, glypican-1, and syndecans 1-3 in the lesions of DAT brain neocortex and hippocampus. Using a panel of specific antibodies directed against the protein backbone of the various HSPG species… CONTINUE READING