Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue.

@article{Gesemann1998AgrinIA,
  title={Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue.},
  author={Matthias Gesemann and Andrea Brancaccio and Beat Schumacher and Markus A. Ruegg},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 1},
  pages={
          600-5
        }
}
Agrin is a basement membrane-associated proteoglycan that induces the formation of postsynaptic specializations at the neuromuscular junction. This activity is modulated by alternative splicing and is thought to be mediated by receptors expressed in muscle fibers. An isoform of agrin that does not induce postsynaptic specializations binds with high affinity to dystroglycan, a component of the dystrophin-glycoprotein complex. Transcripts encoding this agrin isoform are expressed in a variety of… CONTINUE READING
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