Agrin induces phosphorylation of the nicotinic acetylcholine receptor.

@article{Wallace1991AgrinIP,
  title={Agrin induces phosphorylation of the nicotinic acetylcholine receptor.},
  author={Bruce G. Wallace and Zhilin Qu and Richard L. Huganir},
  journal={Neuron},
  year={1991},
  volume={6 6},
  pages={869-78}
}
Agrin causes acetylcholine receptors (AChRs) on chick myotubes in culture to aggregate, forming specializations that resemble the postsynaptic apparatus at the vertebrate skeletal neuromuscular junction. Here we report that treating chick myotubes with agrin caused an increase in phosphorylation of the AChR beta, gamma, and delta subunits. H-7, a potent inhibitor of several protein serine kinases, blocked agrin-induced phosphorylation of the gamma and delta subunits, but did not prevent either… CONTINUE READING

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