Agrin controls synaptic differentiation in hippocampal neurons.

  title={Agrin controls synaptic differentiation in hippocampal neurons.},
  author={Christian M Bose and De-lai Qiu and Andrea Bergamaschi and Biagio Gravante and Mario Bossi and Antonello Villa and Fabio Rupp and Antonio Malgaroli},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 24},
Agrin controls the formation of the neuromuscular junction. Whether it regulates the differentiation of other types of synapses remains unclear. Therefore, we have studied the role of agrin in cultured hippocampal neurons. Synaptogenesis was severely compromised when agrin expression or function was suppressed by antisense oligonucleotides and specific antibodies. The effects of antisense oligonucleotides were found to be highly specific because they were reversed by adding recombinant agrin… CONTINUE READING