Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis.

@article{Yan2018AgrinAL,
  title={Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis.},
  author={Min Yan and Guang-lin Xing and Wen-Cheng Xiong and Lin Mei},
  journal={Annals of the New York Academy of Sciences},
  year={2018},
  volume={1413 1},
  pages={
          126-135
        }
}
Myasthenia gravis (MG) is a common disorder that affects the neuromuscular junction. It is caused by antibodies against acetylcholine receptor and muscle-specific tyrosine kinase; however, some MG patients do not have antibodies against either of the proteins. Recent studies have revealed antibodies against agrin and its receptor LRP4-both critical for neuromuscular junction formation and maintenance-in MG patients from various populations. Results from experimental autoimmune MG animal models… CONTINUE READING