Agrin Can Mediate Acetylcholine Receptor Gene Expression in Muscle by Aggregation of Muscle-derived Neuregulins

@article{Meier1998AgrinCM,
  title={Agrin Can Mediate Acetylcholine Receptor Gene Expression in Muscle by Aggregation of Muscle-derived Neuregulins },
  author={Thomas Meier and Fabrizio Masciulli and Chris Moore and Fabrice Schoumacher and Urs Eppenberger and Alain J. Denzer and Graham Jones and Hans Rudolf Brenner},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={715 - 726}
}
The neural isoforms of agrin can stimulate transcription of the acetylcholine receptor (AChR) epsilon subunit gene in electrically active muscle fibers, as does the motor neuron upon the formation of a neuromuscular junction. It is not clear, however, whether this induction involves neuregulins (NRGs), which stimulate AChR subunit gene transcription in vitro by activating ErbB receptors. In this study, we show that agrin- induced induction of AChR epsilon subunit gene transcription is inhibited… CONTINUE READING

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