Agrin Acts via a MuSK Receptor Complex
@article{Glass1996AgrinAV,
title={Agrin Acts via a MuSK Receptor Complex},
author={David J. Glass and David C. Bowen and Trevor Stitt and Czeslaw H Radziejewski and Joanne Bruno and Terence E. Ryan and David R. Gies and Sonal Shah and Karen Mattsson and Steven J. Burden and Peter S. Distefano and David M. Valenzuela and Thomas M. Dechiara and George D. Yancopoulos},
journal={Cell},
year={1996},
volume={85},
pages={513-523}
}
656 Citations
Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formation
- BiologyCurrent Opinion in Neurobiology
- 1997
The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
- BiologyCell
- 1996
Structural basis of agrin-LRP4-MuSK signaling.
- BiologyGenes & development
- 2012
It is shown that the tetrameric complex is essential for neuronal agrin-induced acetylcholine receptor (AChR) clustering and represent a novel mechanism for activation of receptor tyrosine kinases.
Induction of multiple signaling loops by MuSK during neuromuscular synapse formation
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2001
Agrin activation leads to the establishment of a neuregulin-1-dependent signaling complex that maintains MuSK, ErbB, and AChR expression at the synapse of electrically active muscle fibers.
Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations
- BiologyThe Journal of cell biology
- 1999
The results indicate that the ectodomain of MuSK mediates both agrin- dependent activation of a complex signal transduction pathway and agin-independent association of the kinase with other postsynaptic components.
Tid1 Mediates Agrin and Muscle Specific Kinase Signaling at the Neuromuscular Junction
- Biology
- 2007
Tid1 is implicate as a novel NMJ player and a new class of molecules in the agrin/MuSK signaling cascade is defined, which may reveal mechanisms important for the formation and maintenance of synapses.
Formation of the neuromuscular junction. Agrin and its unusual receptors.
- Biology, ChemistryEuropean journal of biochemistry
- 1999
The picture of the molecular pathway causing the redistribution of synaptic proteins is still incomplete, but many components of the machinery triggering postsynaptic differentiation have now been identified and interactions of the extracellular domain with unknown components are also required.
Signaling complexes for postsynaptic differentiation
- BiologyJournal of neurocytology
- 2003
Results suggest that MuSK may function as a scaffold tyrosine kinase that forms a multi-molecule complex for AChR clustering.
Rapsyn as a signaling and scaffolding molecule in neuromuscular junction formation and maintenance
- BiologyNeuroscience Letters
- 2020
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