Agrin Acts via a MuSK Receptor Complex

  title={Agrin Acts via a MuSK Receptor Complex},
  author={D. Glass and D. Bowen and T. Stitt and C. Radziejewski and Joanne Bruno and T. Ryan and David R. Gies and S. Shah and K. Mattsson and S. Burden and P. Distefano and D. Valenzuela and T. Dechiara and G. Yancopoulos},
  • D. Glass, D. Bowen, +11 authors G. Yancopoulos
  • Published 1996
  • Biology, Medicine
  • Cell
  • Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve terminal with a highly specialized patch on the muscle membrane, termed the motor endplate. Agrin is a nerve-derived factor that can induced molecular reorganizations at the motor endplate, but the mechanism of action of agrin remains poorly understood. MuSK is a receptor tyrosine kinase localized to the… CONTINUE READING
    636 Citations
    Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formation
    • 71
    Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
    • 516
    Induction of multiple signaling loops by MuSK during neuromuscular synapse formation
    • 47
    • PDF
    Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations
    • 145
    • PDF
    Formation of the neuromuscular junction. Agrin and its unusual receptors.
    • W. Hoch
    • Medicine
    • European journal of biochemistry
    • 1999
    • 35
    • PDF
    Structural mechanisms of the agrin–LRP4–MuSK signaling pathway in neuromuscular junction differentiation
    • 44
    Signaling complexes for postsynaptic differentiation
    • 27


    Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
    • 867
    Building synapses: agrin and dystroglycan stick together
    • 100
    Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.
    • 105
    • Highly Influential
    Dystroglycan binds nerve and muscle agrin
    • 274
    The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
    • 248
    • Highly Influential
    • PDF
    Structure and expression of a rat agrin
    • 299
    Developmental regulation of highly active alternatively spliced forms of agrin
    • 183
    Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions
    • 225