Agrin Acts via a MuSK Receptor Complex

  title={Agrin Acts via a MuSK Receptor Complex},
  author={David J Glass and David C. Bowen and Trevor Stitt and Czeslaw Radziejewski and Joanne Bruno and Terence Edward Ryan and David R. Gies and Sonal Patel Shah and Karen I. Mattsson and Steven J Burden and Peter S Distefano and David M. Valenzuela and Thomas M Dechiara and George D. Yancopoulos},
Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve terminal with a highly specialized patch on the muscle membrane, termed the motor endplate. Agrin is a nerve-derived factor that can induced molecular reorganizations at the motor endplate, but the mechanism of action of agrin remains poorly understood. MuSK is a receptor tyrosine kinase localized to the… CONTINUE READING
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