Agrin Acts via a MuSK Receptor Complex

David J Glass; David C. Bowen; Trevor Stitt; Czeslaw Radziejewski; Joanne Bruno; Terence Edward Ryan; David R. Gies; Sonal Patel Shah; Karen I. Mattsson; Steven J Burden; Peter S Distefano; David M. Valenzuela; Thomas M Dechiara; George D. Yancopoulos

Agrin Acts via a MuSK Receptor Complex

@article{Glass1996AgrinAV,
  title={Agrin Acts via a MuSK Receptor Complex},
  author={David J Glass and David C. Bowen and Trevor Stitt and Czeslaw Radziejewski and Joanne Bruno and Terence Edward Ryan and David R. Gies and Sonal Patel Shah and Karen I. Mattsson and Steven J Burden and Peter S Distefano and David M. Valenzuela and Thomas M Dechiara and George D. Yancopoulos},
  journal={Cell},
  year={1996},
  volume={85},
  pages={513-523}
}

David J Glass, David C. Bowen, +11 authors George D. Yancopoulos
Published 1996 in Cell
DOI:10.1016/S0092-8674(00)81252-0

Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve terminal with a highly specialized patch on the muscle membrane, termed the motor endplate. Agrin is a nerve-derived factor that can induced molecular reorganizations at the motor endplate, but the mechanism of action of agrin remains poorly understood. MuSK is a receptor tyrosine kinase localized to the… CONTINUE READING

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5 Figures & Tables

Topics

Receptor Protein-Tyrosine Kinases

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References

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Showing 1-10 of 50 references

J. R. Fallon, Z. W. Hall
1994

Dystrophin-associated proteins and synapse formation: is alpha-dystroglycan the agrin receptor?

Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.

Werner Hoch, James T. Campanelli, Stephen Harrison, Richard H. Scheller
The EMBO journal
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Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

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Agrin induces phosphorylation of the nicotinic acetylcholine receptor.

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Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

Medha Gautam, Peter G. Noakes, +4 authors Joshua R Sanes
Cell
1996

Agrin Acts via a MuSK Receptor Complex

5 Figures & Tables

Topics

Cited By

Sodium nitrate decreases agrin-induced acetylcholine receptor clustering

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

THE UNIVERSITY OF CALGARY Mechanisms of Synapse Formation and Synaptic Plasticity by Collin Chill-Fone Luk A DISSERTATION SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY

Exploration of neuromuscular plasticity : an examination of acetylcholine receptor and skeletal muscle fiber adaptations

The role of postsynaptic AMPA receptors in stabilizing presynaptic inputs

TID 1 MEDIATES AGRIN AND MUSCLE SPECIFIC KINASE SIGNALING AT THE NEUROMUSCULAR JUNCTION by

Expression of Trisk 51, agrin and nicotinic-acetycholine receptor ε-subunit during muscle development in a novel three-dimensional muscle-neuronal co-culture system

The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons

Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome.

Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations

References

Agrin Acts via the MuSK Receptor

Dystrophin-associated proteins and synapse formation: is alpha-dystroglycan the agrin receptor?

Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

ceptor tyrosine kinase specific for the skeltal muscle lineage: ex(1993). Developmental regulation of highly active alternatively pression in embryonic muscle, at the neuromuscualr junction

Agrin induces phosphorylation of the nicotinic acetylcholine receptor.

The fibroblast growth factor family.

Regulation of the interaction of nicotinic acetylceptor specificity

Cross-Linking of Radiolabeled Agrin

Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

Agrin Acts via a MuSK Receptor Complex

5 Figures & Tables

Topics

Cited By

Sodium nitrate decreases agrin-induced acetylcholine receptor clustering

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

THE UNIVERSITY OF CALGARY Mechanisms of Synapse Formation and Synaptic Plasticity by Collin Chill-Fone Luk A DISSERTATION SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY

Exploration of neuromuscular plasticity : an examination of acetylcholine receptor and skeletal muscle fiber adaptations

The role of postsynaptic AMPA receptors in stabilizing presynaptic inputs

TID 1 MEDIATES AGRIN AND MUSCLE SPECIFIC KINASE SIGNALING AT THE NEUROMUSCULAR JUNCTION by

Expression of Trisk 51, agrin and nicotinic-acetycholine receptor ε-subunit during muscle development in a novel three-dimensional muscle-neuronal co-culture system

The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons

Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome.

Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations

References

Agrin Acts via the MuSK Receptor

Dystrophin-associated proteins and synapse formation: is alpha-dystroglycan the agrin receptor?

Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

ceptor tyrosine kinase specific for the skeltal muscle lineage: ex(1993). Developmental regulation of highly active alternatively pression in embryonic muscle, at the neuromuscualr junction

Agrin induces phosphorylation of the nicotinic acetylcholine receptor.

The fibroblast growth factor family.

Regulation of the interaction of nicotinic acetylceptor specificity

Cross-Linking of Radiolabeled Agrin

Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

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