Agrin Acts via a MuSK Receptor Complex

@article{Glass1996AgrinAV,
  title={Agrin Acts via a MuSK Receptor Complex},
  author={D. Glass and D. Bowen and T. Stitt and C. Radziejewski and Joanne Bruno and T. Ryan and David R. Gies and S. Shah and K. Mattsson and S. Burden and P. Distefano and D. Valenzuela and T. Dechiara and G. Yancopoulos},
  journal={Cell},
  year={1996},
  volume={85},
  pages={513-523}
}
  • D. Glass, D. Bowen, +11 authors G. Yancopoulos
  • Published 1996
  • Biology, Medicine
  • Cell
    • Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve terminal with a highly specialized patch on the muscle membrane, termed the motor endplate. Agrin is a nerve-derived factor that can induced molecular reorganizations at the motor endplate, but the mechanism of action of agrin remains poorly understood. MuSK is a receptor tyrosine kinase localized to the… CONTINUE READING
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    References

    SHOWING 1-10 OF 90 REFERENCES
    Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
    • 867
    A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering
    • 373
    Building synapses: agrin and dystroglycan stick together
    • 100
    RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes
    • 204
    Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.
    • 105
    • Highly Influential
    Dystroglycan binds nerve and muscle agrin
    • 274
    The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
    • 248
    • Highly Influential
    • PDF
    Structure and expression of a rat agrin
    • 299
    Developmental regulation of highly active alternatively spliced forms of agrin
    • 183
    Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions
    • 225