Agrin Acts via a MuSK Receptor Complex

@article{Glass1996AgrinAV,
  title={Agrin Acts via a MuSK Receptor Complex},
  author={D. Glass and D. Bowen and T. Stitt and C. Radziejewski and Joanne Bruno and T. Ryan and David R. Gies and S. Shah and K. Mattsson and S. Burden and P. Distefano and D. Valenzuela and T. Dechiara and G. Yancopoulos},
  journal={Cell},
  year={1996},
  volume={85},
  pages={513-523}
}
  • D. Glass, D. Bowen, +11 authors G. Yancopoulos
  • Published 1996
  • Biology, Medicine
  • Cell
  • Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve terminal with a highly specialized patch on the muscle membrane, termed the motor endplate. Agrin is a nerve-derived factor that can induced molecular reorganizations at the motor endplate, but the mechanism of action of agrin remains poorly understood. MuSK is a receptor tyrosine kinase localized to the… CONTINUE READING
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