Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoff.

@article{Carrick2011AgreementAH,
  title={Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoff.},
  author={Danielle Mercatante Carrick and Bryce Ryan Johnson and Steven H. Kleinman and Robert Vorhaben and Suzette C. Chance and Jar-How Lee and John D. Roback and Suchitra Pandey and Yu Sun and Michael P. Busch and Philip J Norris},
  journal={Transfusion},
  year={2011},
  volume={51 5},
  pages={
          1105-16
        }
}
BACKGROUND HLA antibodies might contribute to the pathogenesis of transfusion-related acute lung injury (TRALI). HLA antibody detection methods include ELISA, flow cytometry, and multiplex bead-based assays, as well as the older lymphocytotoxicity assay, and it is not obvious how to compare results across platforms. STUDY DESIGN AND METHODS Five hundred twenty-five serum samples were selected from 7841 donors in the Leukocyte Antibody Prevalence Study (LAPS) repository based on risk for the… CONTINUE READING
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