Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides.

@article{Bleackley2014Agp2pTP,
  title={Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides.},
  author={Mark R Bleackley and Jennifer L. Wiltshire and Francine Perrine-Walker and Shaily Vasa and Rhiannon L Burns and Nicole L. van der Weerden and Marilyn A Anderson},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 5},
  pages={2688-98}
}
Cationic antifungal peptides (AFPs) act through a variety of mechanisms but share the common feature of interacting with the fungal cell surface. NaD1, a defensin from Nicotiana alata, has potent antifungal activity against a variety of fungi of both hyphal and yeast morphologies. The mechanism of action of NaD1 occurs via three steps: binding to the fungal… CONTINUE READING