Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

@article{Lu1994AgoutiPI,
  title={Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor},
  author={Danielle W Lu and Derril H Willard and Indravadan R. Patel and Sue H Kadwell and Laurie K. Overton and Tom A Kost and Michael E. Luther and Wenbiao Chen and Richard P. Woychik and William O. Wilkison and Roger D Cone},
  journal={Nature},
  year={1994},
  volume={371},
  pages={799-802}
}
THE genetic loci agouti and extension control the relative amounts of eumelanin (brown–black) and phaeomelanin (yellow–red) pigments in mammals1: extension encodes the receptor for melano-cyte-stimulating hormone (MSH)2 and agouti encodes a novel 131-amino-acid protein containing a signal sequence3,4. Agouti, which is produced in the hair follicle5, acts on follicular melanocytes6 to inhibit α-MSH-induced eumelanin production, resulting in the subterminal band of phaeomelanin often visible in… CONTINUE READING
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