Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression.

@article{Pfaffinger1988AgonistsTS,
  title={Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression.},
  author={Paul J. Pfaffinger and Mark D. Leibowitz and E M Subers and Neil M. Nathanson and Wolfhard Almers and Bertil Hille},
  journal={Neuron},
  year={1988},
  volume={1 6},
  pages={477-84}
}
The hypothesis that acetylcholine, substance P, and LHRH suppress M-current by activating phospholipase C was tested. Each agonist caused turnover of phosphoinositide, as measured by release of inositol phosphates, and a modest transient rise in intracellular free Ca2+ ([ Ca2+]i), as determined with fura-2. Active phorbol esters depressed M-current only 50% and did not prevent further suppression by LHRH. M-current, its control by agonists, and its depression by phorbol esters were not affected… CONTINUE READING
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