Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.

@article{Shpacovitch2004AgonistsOP,
  title={Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.},
  author={Victoria M. Shpacovitch and Georg Varga and Anke Strey and Matthias Gunzer and Fieke J M Mooren and Joerg Buddenkotte and Nathalie Vergnolle and Christian Sommerhoff and Stephan Grabbe and Volker Gerke and Bernhard Homey and Morley D Hollenberg and Thomas Anton Luger and Martin S Steinhoff},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={76 2},
  pages={388-98}
}
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and allergic or bacterial proteases. This receptor is expressed by various cells and seems to be crucially involved during inflammation and the… CONTINUE READING